The Effects Of Caffeine On Oxidative Stress - 1460 Words

In the present study, the MDA level was measured as an index of lipid peroxidation in order to observe the effect of caffeine on the oxidative stress induced by AlCl3 in cortex, hippocampus and striatum brain areas. Brain tissues are more vulnerable to oxidative stress other than tissues for many reasons such as high oxygen consumption (more than 20% of the total inspired oxygen), the presence of abundant amount of polyunsaturated fatty acids which are susceptible to free radicals attack, low antioxidant levels, high iron content in addition to the non-regenerative nature of neurons (Nehru and Anand, 2005; Kim et al., 2015). All these reasons may explain why brain is more susceptible to aluminum toxicity than other organs. In the present†¦show more content†¦The present results showed that daily protection with caffeine attenuated the increase in MDA levels in AlCl3-intoxicated rats. Supporting the present finding, previous studies have revealed the antioxidant potential of caffeine against lipid peroxidation in various animal models of neurologic diseases, including Alzheimer’s disease (Prasanthi et al., 2010), epilepsy (Souza et al., 2013) and Parkinsons disease (Khadrawy et al., 2017). It has been demonstrated that caffeine has the ability to scavenge reactive oxygen species (Devasagayam et al., 1996) and modulated the brain antioxidant system through increasing the content of GSH and activities of antioxidant enzymes like glutathione reductase and superoxide dismutase (Abreu et al., 2011). Generally, the antioxidant capacity of caffeine was similar to that of the established biological antioxidant GSH and significantly higher than ascorbic acid (Devasagayam et al., 1996). Accordingly, this may explain the ability of caffeine to attenuate lipid peroxidation induced by AlCl3 in the current study via direct scavenging of reactive oxygen species or by increasing GSH content and antioxidant enzymes activities. The present data revealed that daily oral administration of AlCl3 resulted in a significant increase in NO levels in the cortex, hippocampus and striatum. NO is the smallest signalling molecule withinShow MoreRelatedThe Depletion Of The Rat Model Of Monoamine1295 Words   |  6 PagesIn the present study, the rat model of depression induced by reserpine was used to evaluate whether caffeine could treat depression or exaggerate it. The present data revealed that the daily reserpine treatment for 30 days induced a significant decrease in the cortical and hippocampal serotonin, norepinephrine and dopamine levels. In addition, a decrease in the motor activity was observed. 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