The Effects Of Caffeine On Oxidative Stress - 1460 Words

In the present study, the MDA level was measured as an index of lipid peroxidation in order to observe the effect of caffeine on the oxidative stress induced by AlCl3 in cortex, hippocampus and striatum brain areas. Brain tissues are more vulnerable to oxidative stress other than tissues for many reasons such as high oxygen consumption (more than 20% of the total inspired oxygen), the presence of abundant amount of polyunsaturated fatty acids which are susceptible to free radicals attack, low antioxidant levels, high iron content in addition to the non-regenerative nature of neurons (Nehru and Anand, 2005; Kim et al., 2015). All these reasons may explain why brain is more susceptible to aluminum toxicity than other organs. In the present†¦show more content†¦The present results showed that daily protection with caffeine attenuated the increase in MDA levels in AlCl3-intoxicated rats. Supporting the present finding, previous studies have revealed the antioxidant potential of caffeine against lipid peroxidation in various animal models of neurologic diseases, including Alzheimer’s disease (Prasanthi et al., 2010), epilepsy (Souza et al., 2013) and Parkinsons disease (Khadrawy et al., 2017). It has been demonstrated that caffeine has the ability to scavenge reactive oxygen species (Devasagayam et al., 1996) and modulated the brain antioxidant system through increasing the content of GSH and activities of antioxidant enzymes like glutathione reductase and superoxide dismutase (Abreu et al., 2011). Generally, the antioxidant capacity of caffeine was similar to that of the established biological antioxidant GSH and significantly higher than ascorbic acid (Devasagayam et al., 1996). Accordingly, this may explain the ability of caffeine to attenuate lipid peroxidation induced by AlCl3 in the current study via direct scavenging of reactive oxygen species or by increasing GSH content and antioxidant enzymes activities. The present data revealed that daily oral administration of AlCl3 resulted in a significant increase in NO levels in the cortex, hippocampus and striatum. NO is the smallest signalling molecule withinShow MoreRelatedThe Depletion Of The Rat Model Of Monoamine1295 Words   |  6 PagesIn the present study, the rat model of depression induced by reserpine was used to evaluate whether caffeine could treat depression or exaggerate it. The present data revealed that the daily reserpine treatment for 30 days induced a significant decrease in the cortical and hippocampal serotonin, norepinephrine and dopamine levels. In addition, a decrease in the motor activity was observed. 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Methods: Seventy five healthy albino Wistar rats were divided into 5 groups; the first group received intraperitoneal injection of saline and served as control, 2nd group received a single subcutaneous injectionRead MoreCoffee Consumption : The Health Benefits1831 Words   |  8 Pagesbeverage [1]. I really did not have much background information prior on coffee, just that I need three cups a day to even function. This is because coffee is the richest source of caffeine for Americans, accounting for 71% of caffeine intake [2]. Eight ounces of coffee typically contains between 95 to 200 mg of caffeine [2]. Drinking so much coffee for about seven years of my life really got me thinking, what was I actually consuming? What are health the health benefits? Rubiaceae and Genera CoffeaRead MoreReverse Transcriptase Polmerase Chain, Reaction is an Essential Tool in Molecular Biology1553 Words   |  6 Pagesof the brain. Studies have even shown that caffeine, a non-selective adenosine receptor antagonist, can have an impact on the regulation of the adenosine A1 receptor. Particularly, caffeine administration in rats decreased the number of adenosine A1 receptors in maternal and fetal rat brain tissue, which was related to an increase in mRNA levels (Porcià ºncula 598). Additionally, the positive effects of chronic coffee intake, such as the beneficial effects against memory decline in brain disordersRead MoreSocial And Social Support And Spirituality1590 Words   |  7 Pagesfor the majority of her family’s bills and her estranged spouse provides minimally for the family. 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EverydayRead MoreThe Effect Of Cocoa Powder, White Chocolate And Dark Chocolate On Oxidative Stress And Lipid Profile On Hypercholesterolemic Rats1953 Words   |  8 PagesThe Effect of Cocoa Powder, White Chocolate and Dark Chocolate on Oxidative Stress and Lipid Profile on Hypercholesterolemic Rats FadlAlla, Eman Aly Sadeek1, Saffa Moustapha Abd El Fatah Faid2 1Department of Biochemistry NutritionWomen s College , Ain Shams University, Egypt. 2 Home Economics Dept. Faculty of specific Education, Ain Shams University, Egypt. dr_emansaddeek@yahoo.com Abstract: Aim of the work: Assessing the effect of cocoa powder, white chocolate and dark chocolate on oxidativeRead MoreOsteoporosis Is An Age Related Disease Of The Skeletal System1493 Words   |  6 Pagesosteoporosis should increase their intake of calcium from the recommended daily amount. Phosphorus is also important in the diet, but should be taken in consideration with calcium intake, where higher phosphorus levels than calcium can have negative effects on bone health. However, when taken at sufficient levels, with calcium, phosphorus can increase bone density. A diet that lacks phosphorus can â€Å"limit osteoblast function and enhance osteoclastic resorption†.(AJCN) Vitamin D and calcium ha a correlation

A Streetcar Named Desire Different Personalities Free Essays

In the classic film, A Streetcar Named Desire, there are four main characters with four very different personalities. While Stanley is the definite dominant male, controlling and demanding to his wife, Stella, who has learned to tolerate his personality; Mitch is the overall average good guy, desiring nothing short of a normal life with a loving wife. Blanche is the main character in the story and is the sister of Stella. We will write a custom essay sample on A Streetcar Named Desire: Different Personalities or any similar topic only for you Order Now The two of them have been apart over the years and recently came together again. With the past haunting her trail, Blanche tries to run far beyond it. Stanley doesn’t help matters any with his accusations against her.Being left in charge of the family estate, Blanche loses it all, but Stanley isn’t convinced of that. He is convinced that she has sold it and his attempt to find out where he and Stella’s half of the money from the estate went, only forces Blanche closer to the edge of insanity. Blanche’s response to Stanley’s dominant personality was appealing to her upon meeting Stanley and she found herself rather attracted to him, but these feelings soon changed for the both of them. Stanley and Blanche’s characters bring to surface the worse possible dynamics, creating a clashing relationship. Stanley’s character represents that of the strong, egotistical type, which molds the character of Stella into a nervous, agitated individual who must try to keep Stanley from causing her sister more grief. Stanley’s strength could be noted as his persistent personality while Stella’s emotional strength and level-headedness would be the power to hold the relationship together. The timing of Stella’s sister’s return only enhanced the heights of the arguments between Stanley and his wife. For Stanley, Blanche was a threat by increasing the insecurity he had of whether or not Stella really would return to him after each fight.The feeling of the unknown only made him more aggressive. Mitch’s character was displayed as sensitive and loyal, which was a strength in the short relationship he had with Blanche. With his mother’s dying wish to see him settled down, Mitch is attracted to the hidden, soft heart of Blanche. Blanche’s tender heart was a powerful dynamic of the relationship with Mitch, as he was able to reveal the desire of her to do well. His loyalty to doing what is right backfires when it pushes Blanche completely out after her horrible past is revealed to Mitch, thus revealing the terrible timing in life of the two meeting each other.The ambiguity of a future for these two left Mitch with absolutely no confidence that it would work, which explains his decision to end the relationship with Blanche before it escalated anymore. Timing of this story along with the fact that all the characters feared the unknown, truly impacted the tension in the setting. There was a high strung, outlandish feeling in the air with each personality of the play that caused the tight narrative tension. While the desires of each character may have been to succeed, the ambiguity caused them all to lose out on what might have been. How to cite A Streetcar Named Desire: Different Personalities, Papers

Romeo And Juliet Why They Died Essay Example For Students

Romeo And Juliet Why They Died Essay Romeo Juliet EssayRomeo and Juliet is about two young lovers born of different rivaling families. The two lovers fall in love only too find that their families are enemies. Romeo wants to stop at nothing to have Juliet his love. The feud soon causes their deaths and many others hurt. In the beginning the feud is reignited by these simple lines: If you start a quarrel Im ready. My master is as good as your master. (I, i, 44) This brought Benvolio in to the fight. Benvolio tries to stop the fight but Tybalt the hot headed Capulet attacks him. Montague and Capulet charge at each other swords defining each other. The Prince arrives and orders them to stop. He threatens the Families with their lives. With this the Feud is rekindled. In Act II Benovlio, Mercutio, Romeo crash the Capulets party. Romeo spots Juilet for the first time and is awe struck by her beauty: That I never saw real beauty until tonight (II, V, 53) Tybalt over hears this and is enraged: That man has the voice of Montague. And he tries to attack Romeo but Capulet hold him back. Romeo and Juilet finally meet and fall in love. Later the Famous Scene between Romeo and Juliet happens. Being irrational they ran to get married. This will cause a lot of problems to come. Act III is the feud climax. Mercutio dies by the wound inflicted by Tybalt after they meet and fight over Romeo. Romeo tried to stop them but he couldnt and the sword of Tybalt went under his arm and sliced Mercutios breast. Tybalt ran away after the death of Mercutio. Romeo is sadden and realizes his love for Juliet has blinded him. Furious over his friends death he slays Tybalt when he returns. The Prince arrives after Benvolio told Romeo to run. Benvolio tells the Prince what happened and the Prince orders Romeos banishment: Romeo killed him but Tybalt killed Mercutio. Who to pa the price of Mercutios death. All are grieve stricken for now they relize how deadly there conflict has become. Act V is the end heart broken from her sons banishment Lady Montague dies. Capulet is forcing her to marry Paris Nobleman and relative of the Prince. Juliet not wanting to marry him goes to the friar Lawrence and asks for advice. The Friar gives poorly given advice and tells her to drink a potion that will feign her death for 42 hours. He was suppose to send a letter to Romeo but Romeo never received it. Meanwhile Romeos servant told him of her death. Enraged he goes and gets poison. Later Paris finds Romeo and attacks him Romeo Enraged and Saddened kills Paris. Romeo drinks the poison as Juliet wakes. Juliet takes her knife and kills her self with it. The Play is a classic the feud was torrent but never to strong to over come for only after the death of their beloved children did Montague and Capulet finally the feud ends. There killed many innocent people.